TY - JOUR
TI - SOLID-PHASE SYNTHESIS OF A SOMATOSTATIN AMIDE ANALOG USING ACID LABILE
TERT-BUMEOC PROTECTION AND AN ACID LABILE ANCHOR GROUP
AU - VOELTER, W
AU - BREIPOHL, G
AU - TZOUGRAKI, C
AU - JUNGFLEISCHTURGUT, E
JO - Collection of Czechoslovak Chemical Communications
PY - 1992
VL - 57
TODO - 8
SP - 1707-1718
PB - INST ORGANIC CHEM AND BIOCHEM
SN - 0010-0765, 1212-6950
TODO - 10.1135/cccc19921707
TODO - null
TODO - The solid phase synthesis of an amidated somatostatin analogue based on
the principle of differentiated acidolysis is described. The acid labile
and smoothly cleavable t-Bumeoc moiety (1% TFA/DCM) is used for
temporary N(alpha)-protection of D- and L-amino acids and
[4-[[[9H-fluoren-9-yl-methoxycarbonyl]amino](4-methoxyphenyl)met
hyl]-2-methylphenoxy]acetic acid, attached to an aminomethylated
polystyrene resin is used as acid sensitive linker of the solid carrier
which releases the peptide in its amide form by treatment with TFA. Its
preparation is described in detail.
ER -