TY - JOUR
TI - TREATMENT OF POLYCYSTIC OVARIAN DISEASE DURING ADOLESCENCE WITH
ETHINYLESTRADIOL CYPROTERONE-ACETATE VERSUS A D-TR-6-LHRH ANALOG
AU - CREATSAS, G
AU - HASSAN, E
AU - DELIGEOROGLOU, E
AU - TOLIS, G and
AU - ARAVANTINOS, D
JO - International Journal of Gynecology and Obstetrics
PY - 1993
VL - 42
TODO - 2
SP - 147-153
PB - ELSEVIER SCI IRELAND LTD
SN - 0020-7292
TODO - 10.1016/0020-7292(93)90629-B
TODO - POLYCYSTIC OVARIAN DISEASE; ADOLESCENCE; LHRH ANALOG; CYPROTERONE
ACETATE; HIRSUTISM; OLIGOMENORRHEA
TODO - OBJECTIVE: This study was undertaken to compare the clinical and
endocrinological results of two kinds of treatment on adolescents with
polycystic ovarian disease (PCOD). METHOD: Forty-five adolescents with
PCOD were randomly allocated into two groups, treated either with
ethinylestradiol (EE)/cyproterone acetate (group A) or the GnRH analog
D-Tr-6-LHRH (group B). RESULT: No significant changes were detected on
the body mass index and waist-hip circumference. A significant
improvement of hirsutism was noticed in both groups of patients. A
normal menstrual period was recorded in group A adolescents while all
group B patients became amenorrheic. A favorable decrease of ovarian
volume was detected in both groups. LH/FSH ratio and
DELTA4-androstenedione serum levels were found significantly reduced in
both groups in comparison to pre-treatment levels. The comparison
between the two groups, after 6 months, showed significantly lower
values of LH/FSH ratio in group B cases. CONCLUSION: Both forms of
treatment are safe and effective to a various degree for the management
of PCOD adolescents.
ER -