TY - JOUR
TI - INCREASED FREQUENCY OF HLA B17 ANTIGEN IN GIRLS WITH TURNER SYNDROME AND
THEIR FATHERS
AU - DACOUVOUTETAKIS, C
AU - GEORGOPOULOS, N
AU - PAPPA, H
AU - VLACHOS, K and
AU - TARASSI, K
AU - CHRYSSOVERGI, D
AU - PAPASTERIADES, C
JO - Disease Markers
PY - 1993
VL - 11
TODO - 5-6
SP - 263-266
PB - HINDAWI LTD
SN - 0278-0240, 1875-8630
TODO - 10.1155/1993/243295
TODO - TURNER SYNDROME; HLA ANTIGENS
TODO - HLA-A, -B and -DR antigen distribution was studied in 49 girls with
Turner Syndrome (TS), in 43 of their parents, as well as in 433
controls. No increased frequency of DR3, DR4 was found in our group.
However, an increased frequency of HLA B17 antigen was disclosed (18.3%
in TS versus 6.4% in the controls, p<0.001 and p(c<)0.01). Furthermore,
the HLA B17 antigen was of paternal origin in 77.7% of the cases. The
interpretation of the present findings is quite difficult. Most likely,
the findings are related to the chromosomal abnormality rather than to
autoimmunity. It is quite possible that genes within the region of class
I genes create unfavorable circumstances leading to the loss of the sex
chromosome or, alternatively, genes in this region confer protection and
prevent miscarriage of the affected fetus.
ER -