TY - JOUR
TI - EFFECTS OF PROPOFOL AND THIOPENTONE ON POLYMORPHONUCLEAR LEUKOCYTE
FUNCTIONS IN-VITRO
AU - SKOUTELIS, A
AU - LIANOU, P
AU - PAPAGEORGIOU, E
AU - KOKKINIS, K and
AU - ALEXOPOULOS, K
AU - BASSARIS, H
JO - Acta Anaesthesiologica Scandinavica
PY - 1994
VL - 38
TODO - 8
SP - 858-862
PB - MUNKSGAARD INT PUBL LTD
SN - 0001-5172, 1399-6576
TODO - 10.1111/j.1399-6576.1994.tb04018.x
TODO - ADHERENCE; ANESTHETICS; CHEMOTAXIS; KILLING; LEUKOCYTE; PHAGOCYTOSIS;
PROPOFOL; THIOPENTONE
TODO - Anaesthetic agents may impair host defense mechanisms including
polymorphonuclear leukocyte (PMNL) function.
We have studied the effects of thiopentone and propofol in low
(thiopentone Ia mg/L, propofol 2 mg/l) and high (thiopentone 40 mg/L,
propofol 6 mg/L) clinically relevant concentrations on PMNL adherence,
chemotaxis, phagocytosis and killing in vitro.
The results demonstrated that thiopentone in both concentrations
significantly decreases all PMNL functions tested and had a direct
influence on the PMNLs in terms of their chemotactic response. In
contrast, propofol decreases significantly only PMNL chemotaxis but not
adherence, phagocytosis and killing. The effect of propofol was not
attributable to the lipid carrier vehicle, as Intralipid with same
formulation had no effect on PMNL function.
We conclude that propofol is a relatively safe agent from the Viewpoint
of PMNL function in vitro, which may be of potential clinical benefit.
ER -