TY - JOUR
TI - BIOGENIC-AMINE METABOLITES IN DELUSIONAL (PSYCHOTIC) DEPRESSION AND
MELANCHOLIA SUBTYPES OF MAJOR DEPRESSION
AU - LYKOURAS, L
AU - MARKIANOS, M
AU - HATZIMANOLIS, J
AU - MALLIARAS, D and
AU - STEFANIS, C
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
PY - 1994
VL - 18
TODO - 8
SP - 1261-1271
PB - PERGAMON-ELSEVIER SCIENCE LTD
SN - 0278-5846
TODO - 10.1016/0278-5846(94)90092-2
TODO - DELUSIONAL DEPRESSION; URINARY HOMOVANILLIC ACID; URINARY
5-HYDROXY-INDOLEACETIC ACID; URINARY 3-METHOXY-4-HYDROXYPHENYLGLYCOL
TODO - 1. The levels of the urinary main metabolites of norepinephrine
3-methoxy-n-hydroxyphenylglycol (MHPG), of dopamine homovanillic acid
(HVA) and of serotonin 5-hydroxyindoleacetic acid (5-HIAA) were measured
in 84 patients with major depressive disorder, 34 delusional and 50
nondelusional. Melancholia subtype was also defined (N=62).
2. MHPG was significantly higher in the delusional depressed group
(p=0.023), Female patients with delusional major depression also had
significantly higher HVA excretion than female patients with non
delusional major depression (p=0.036). 5-HIAA excretion was similar in
the two patient subgroups.
3. No significant differences in the three monoamine metabolites were
found between the melancholic and nonmelancholic depressed patients.
ER -