TY - JOUR
TI - EFFECT OF ACUTE ALLOGRAFT-REJECTION ON EXERCISE HEMODYNAMICS IN PATIENTS
WHO HAVE UNDERGONE CARDIAC TRANSPLANTATION
AU - NANAS, JN
AU - ANASTASIOUNANA, MI
AU - SUTTON, RB
AU - TSAGARIS, TJ
JO - Chest
PY - 1995
VL - 107
TODO - 6
SP - 1517-1521
PB - ELSEVIER SCIENCE BV
SN - 0012-3692, 1931-3543
TODO - 10.1378/chest.107.6.1517
TODO - ALLOGRAFT REJECTION; CARDIAC TRANSPLANTATION; CYCLOSPORINE; EXERCISE
HEMODYNAMICS
TODO - The effect of acute allograft rejection on exercise hemodynamics was
evaluated in 8 consecutive cardiac allograft recipients (group 1) when
the right ventricular endomyocardial biopsy showed evidence of allograft
rejection (R), and when no evidence of rejection (NR) was present. A
separate group of 10 cardiac transplant recipients (group 2) with no
evidence of rejection on biopsy done at the end of the first and second
year posttransplantation served as controls. The exercise hemodynamics
were abnormal in both groups in both studies with a moderate increase of
the pulmonary artery wedge pressure to a mean of 17.2 (NR) and 19.4 mm
Hg (R) in group 1 (p=not significant [NS]) and 20.1 and 21.2 mm Hg in
group 2 (p=NS), a mild increase of the mean right atrial pressure to a
mean of 10 mm Hg (NR) and 10 mm Hg(R) in group 1 (p=NS), 11.9 mm Hg and
12.5 mm Hg in group 2 (p=NS), and a moderate increase of the
arteriovenous oxygen content difference to a mean of 8.5(NR) and 8.4 vol
percent IR) in group 1 and 8.3 and 8.0 vol percent in group 2. No
significant difference was observed between the two studies of the same
group in any of the hemodynamic parameters except for the heart rate in
group 1 (from 91+/-16 to 97+/-16 beats/min [p<0.05] with and without
evidence of allograft rejection, respectively). In conclusion, heart
transplant recipients do not usually manifest further exercise
hemodynamic deterioration during mild to moderate rejection.
ER -