TY - JOUR
TI - N-BUTYL-2-CYANOACRYLATE (HISTOACRYL) PLUS SCLEROTHERAPY VERSUS
SCLEROTHERAPY ALONE IN THE TREATMENT OF BLEEDING ESOPHAGEAL-VARICES - A
RANDOMIZED PROSPECTIVE-STUDY
AU - FERETIS, C
AU - DIMOPOULOS, C
AU - BENAKIS, P
AU - KALLIAKMANIS, B and
AU - APOSTOLIDIS, N
JO - Gastrointestinal Endoscopy
PY - 1995
VL - 27
TODO - 5
SP - 355-357
PB - Georg Thieme Verlag
SN - 0016-5107
TODO - 10.1055/s-2007-1005713
TODO - null
TODO - Background and Study Aims: N-2-cyanoacrylate (Histoacryl) and endoscopic
sclerotherapy with polidocanol have both been reported to control
variceal bleeding, The aim of the present study was to compare the
effectiveness of the combination of Histoacryl and endoscopic
sclerotherapy with polidocanol in the management of these patients
regarding early rebleeding and hospital mortality rates.
Patients and Methods: One hundred twenty-six consecutive patients with
variceal hemorrhage treated with injection therapy between March 1990
and July 1993 were included in this randomized prospective study.
Sixty-seven patients (Group A) were treated with Histoacryl and
conventional sclerotherapy with polidocanol, acid 59 patients (Group B)
were treated with conventional sclerotherapy with polidocanol alone,
Histoacryl was injected intravariceally during the first session in the
Group A patients.
Results: A significantly lower bleeding recurrence rate was found in
Group A patients who presented with active bleeding at the first
treatment session (Group A: 2 of 20, Group B: 8 of 18, p < 0.05), The
hospital mortality was also significantly lower in these patients (Group
A: 3 of 21, Group B: 9 of 18, p < 0.05).
Conclusions: The combination of Histoacryl with conventional
sclerotherapy with polidocanol in patients with esophageal bleeding who
present with active bleeding, at the initial injection therapy, can
improve the results of endoscopic management.
ER -