TY - JOUR
TI - EFFECT OF TESTOSTERONE ADMINISTRATION, PRENATALLY AND POSTNATALLY, ON
THE IMMUNE-SYSTEM OF RATS
AU - KONSTADOULAKIS, MM
AU - SYRIGOS, KN
AU - BAXEVANIS, CN
AU - SYRIGOU, EI and
AU - PAPAMICHAIL, M
AU - PEVERETOS, P
AU - ANAPLIOTOU, M
AU - GOLEMATIS, BC
JO - Hormone and Metabolic Research
PY - 1995
VL - 27
TODO - 6
SP - 275-278
PB - Georg Thieme Verlag KG
SN - 0018-5043, 1439-4286
TODO - 10.1055/s-2007-979958
TODO - IMMUNE SYSTEM; RATS; GONADECTOMY; TESTOSTERONE ADMINISTRATION; STEROID
HORMONES
TODO - This study was undertaken to investigate and compare in vitro and in
vivo immune parameters between female and male rats. We analysed the
T-cell proliferative responses to syngeneic and allogeneic cellular
antigens (syngeneic and allogeneic mixed lymphocyte reaction), as well
as the IgG levels in the sera of our study groups. It has also been
studied the influence of gonadectomy and the effect of testosterone
administration pre- and postnatally on the above parameters. Our
findings showed that hormonal manipulations, can alter the differences
observed in immune response between female and male rats. In addition,
it is demonstrated that pre- and postnatal sexual steroid manipulations
could provoke long lasting immunological effects.
ER -