TY - JOUR
TI - ASSOCIATION OF BIOGENIC-AMINE METABOLITES WITH SYMPTOMATOLOGY IN
DELUSIONAL, (PSYCHOTIC) AND NONDELUSIONAL DEPRESSED-PATIENTS
AU - LYKOURAS, L
AU - MARKIANOS, M
AU - HATZIMANOLIS, J
AU - MALLIARAS, D and
AU - STEFANIS, C
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
PY - 1995
VL - 19
TODO - 5
SP - 877-887
PB - PERGAMON-ELSEVIER SCIENCE LTD
SN - 0278-5846
TODO - 10.1016/0278-5846(95)00117-E
TODO - DELUSIONAL DEPRESSION; HAMILTON DEPRESSION RATING SCALE; URINARY
HOMOVANILLIC ACID; URINARY 5-HYDROXYINDOLEACETIC ACID; URINARY
3-METHOXY-4-HYDROPHENYLGLYCOL
TODO - 1. The levels of the main norepinephrine, serotonin, and dopamine
metabolite excretion in the urine, MHPG, 5HIAA and HVA respectively,
were measured in 84 patients with major depressive disorder, 34
delusional (psychotic) and 50 nondelusional (DSM-III-R criteria).
2. Associations with the 17 items of the HDRS were evaluated using the
multiple regression analysis model. In the delusional group, MHPG
excretion was positively related to the scores in the items of depressed
mood (p=0.04), middle insomnia (p=0.008) and genital symptoms (p=0.001).
5HIAA excretion was negatively associated with late insomnia (p=0.02),
work and interests (p=0.001) and genital symptoms (p=0.007). HVA was
positively related to agitation (p=0.043). In the nondelusional group
the only association found was between agitation and HVA excretion
(p=0.03).
ER -