TY - JOUR
TI - In vitro release of new quinolones from biodegradable systems: A
comparative study
AU - Andreopoulos, AG
AU - Korakis, T
AU - Dounis, E
AU - Anastasiadis, A and
AU - Tzivelekis, P
AU - Kanellakopoulou, K
JO - Journal of Biomaterials Applications
PY - 1996
VL - 10
TODO - 4
SP - 338-347
PB - Technomic Publ Co Inc, Lancaster, PA, United States
SN - 0885-3282, 1530-8022
TODO - 10.1177/088532829601000404
TODO - biodegradable polymers; drug delivery systems; new quinolones;
ofloxacin; ciprofloxacin
TODO - A new biodegradable delivery system based on low molecular weight
poly(lactic acid) has been formualted, with potential application in the
sustained antibiotic release against bone infection. The in vitro
release of two new quinolones (ofloxacin and ciprofloxacin) from the
biodegradable matrix showed that the delivery of ofloxacin from the
matrix lasted fifty-six days, whereas that of ciprofloxacin lasted
fifty-one days. In both cases, release is controlled by the drug
diffusion and the matrix degradation, the latter being the most critical
factor. The obtained concentration levels are well above the Minimum
Inhibitory Concentration (MIC) against the major causative bacteria of
osteomyelitis. This fact in combination with the good reproducibility of
measurements indicated that the system studied could be of value for the
preparation of implantable controlled release systems for treatment of
diseases in the bone system.
ER -