TY - JOUR
TI - A comparative study of an estradiol-releasing vaginal ring versus
tibolone in postmenopausal women: A transvaginal color Doppler study
AU - Botsis, D
AU - Kassanos, D
AU - Kalogirou, D
AU - Antoniou, G and
AU - Karakitsos, P
AU - Zourlas, PA
JO - Maturitas
PY - 1997
VL - 27
TODO - 1
SP - 77-83
PB - Elsevier Ireland Ltd
SN - 0378-5122
TODO - 10.1016/S0378-5122(97)01105-5
TODO - estrogen replacement therapy; tibolone; vaginal ring; endometrial blood
flow; transvaginal Doppler
TODO - Objective: To evaluate endometrial blood flow characteristics in
response to estrogen replacement therapy (ERT) and tibolone in
postmenopausal women and to correlate the resistance index (RI) with
plasma estradiol levels. Materials and methods: Transvaginal color
Doppler ultrasound examinations were performed in 72 asymptomatic,
postmenopausal women who demonstrated endometrial thickness less than or
equal to 5 mm. Thirty-six women receiving tibolone and 36 patients
receiving ERT by a vaginal ring comprised the study groups. Results: All
postmenopausal women treated with tibolone or ERT showed continuous
forward end-diastolic flow. The lowest RI was obtained in women with the
vaginal ring inserted. The plasma concentrations of estradiol were found
to be significantly higher in the vaginal ring group than those of
tibolone. Conclusions: The data observed suggest that ERT and tibolone
modify normal postmenopausal endometrial perfusion. Tibolone had a
weaker estrogenic effect on endometrial blood flow resistance, and
vaginal ring treatment enhanced endometrial blood perfusion through
vasodilatation. (C) 1997 Elsevier Science Ireland Ltd.
ER -