TY - JOUR
TI - Changes of angiogenin serum concentrations in the perinatal period
AU - MalamitsiPuchner, A
AU - Sarandakou, A
AU - Giannaki, G
AU - Rizos, D and
AU - Phocas, I
JO - Pediatric Research
PY - 1997
VL - 41
TODO - 6
SP - 909-911
PB - Lippincott, Williams & Wilkins
SN - 0031-3998, 1530-0447
TODO - 10.1203/00006450-199706000-00018
TODO - null
TODO - The polypeptide angiogenin, a normal constituent of human plasma, might
be involved in endothelium homeostasis, angiogenesis, and
neovascularization accompanying various diseases. This study aimed at
determining angiogenin serum concentrations in the perinatal period of
healthy newborns and at forming a baseline for this protein, which in
the future may serve as a diagnostic index in developmental errors of
the placenta and/or newborn. One milliliter of blood was drawn on d 1
and 4 of life from 30 healthy full-term neonates, and angiogenin serum
concentrations were measured by an enzyme immunoassay using a
commercially available kit. In 10 cases angiogenin serum concentrations
were also measured in the maternal serum before delivery and in the
umbilical vein serum. Angiogenin serum concentrations (mu g/L) were
significantly higher in maternal serum (225.7 +/- 49.6) compared with
umbilical vein serum (119.0 +/- 34.2) (p < 0.0002), as well as that
compared with day 1 (166.4 +/- 44.9) (p < 0.01) but not to d 4 neonatal
serum (240.8 +/- 52.6). Angiogenin serum concentrations showed a
statistically significant increase from d 1 to 4 (p < 10(-7)), as well
as from umbilical cord serum to d 1 neonatal serum (p < 0.0002). A
statistically significant correlation existed between values in
umbilical cord serum and d 1 neonatal serum (r = 0.84, n = 10, p <
0.002) and between those in d 1 and 4 neonatal serum (r = 0.37, n = 30,
p < 0.04). Sex, birth weight, or mode of delivery did not influence
angiogenin serum concentrations. We conclude that a rapid increase of
angiogenin serum concentrations to maternal levels takes place during
the first four postnatal days in healthy full-term neonates.
ER -