TY - JOUR
TI - Comparison of the efficacy and tolerability of clarithromycin suspension
and cefuroxime axetil suspension in the treatment of acute otitis media
in paediatric patients
AU - Kafetzis, DA
AU - MalakaZafiriou, C
AU - Bairamis, T
AU - Roilides, E and
AU - Valeri, R
AU - Stamler, DA
JO - Clinical Drug Investigation
PY - 1997
VL - 14
TODO - 3
SP - 192-199
PB - Adis International Ltd
SN - 1173-2563
TODO - 10.2165/00044011-199714030-00005
TODO - null
TODO - This single-blind, randomised study compared clinical outcomes for
patients aped 5 months to 5 years with otitis media who were treated
with either clarithromycin (7.5 mg/kg twice daily) or cefuroxime axetil
(10 to 15 mg/kg twice daily) for 7 days. Demographics were comparable
fur the two groups. Clinical success (clinical cure, clinical cure with
effusion or improvement) was observed in 96% (66 of 69) of the
clarithromycin group and 94% (63 of 67) of the cefuroxime axetil
recipients. Recurrence occurred in 2 clarithromycin and 4 cefuroxime
patients 4 weeks post-treatment. Eleven of 77 clarithromycin-treated and
11 of 75 cefuroxime axetil-treated patients experienced adverse events.
Among these only 3 patients treated with clarithromycin (4%) and 5
patients treated with cefuroxime axetil (6%) discontinued use because
of adverse events, none of which were serious. Clarithromycin suspension
was well tolerated and highly effective in the treatment of otitis media
in children, and was comparable with cefuroxime axetil when administered
for 7 days.
ER -