TY - JOUR
TI - Evidence that adult life risk factors influence the expression of
familial propensity to breast cancer
AU - Katsouyanni, K
AU - Signorello, LB
AU - Lagiou, P
AU - Egan, K and
AU - Trichopoulos, D
JO - Epidemiology Monitor
PY - 1997
VL - 8
TODO - 5
SP - 592-595
PB - Lippincott, Williams & Wilkins
SN - null
TODO - 10.1097/00001648-199709000-00019
TODO - familial breast cancer; risk factors; interaction; case control study
TODO - In the context of a study in Athens comprising 692 cases and 1,261
controls, we have evaluated the effect on breast cancer risk of the
joint action of first-degree relative family history and established
adult life risk factors. We created a risk score by assigning the value
of 1 to women at high risk with respect to any of these risk factors and
0 otherwise, and summing these values, using weights equal to the excess
odds ratio. The odds ratio for a tertile increment in the risk score was
1.5 [95% confidence interval (CI) = 1.3-1.8] among women without
family history, and 2.3 (95% CI = 1.1-5.1) for women with family
history. Our findings imply that women with a family history of breast
cancer may benefit disproportionately by reduced exposure to adult life
risk factors.
ER -