TY - JOUR
TI - Inflammatory cytokines in newborn infants
AU - Sarandakou, A
AU - Giannaki, G
AU - Malamitsi-Puchner, A
AU - Rizos, D and
AU - Hourdaki, E
AU - Protonotariou, E
AU - Phocas, I
JO - Mediators of Inflammation
PY - 1998
VL - 7
TODO - 5
SP - 309-312
PB - Carfax publ. co.
SN - 0962-9351, 1466-1861
TODO - 10.1080/09629359890811
TODO - IL-1 beta; IL-6; TNF-alpha; neonatal serum; maternal serum; umbilical
cord; labour; neonatal immune response; perinatal period; early neonatal
life; normal values of serum inflammatory cytokines in neonates
TODO - SERUM levels of IL-1 beta, IL-6 and TNF-alpha were measured in 48
healthy, termed neonates on the Ist (N1), 5th (N5) and 40th (N40) day
after birth, compared with those in maternal serum CMS), umbilical cord
(UC) and adult controls. Cytokine values in NI and N5 were significantly
elevated, than those in UC and in controls (P<0.0001). IL-1 beta and
IL-6 declined significantly from NI to N40 (P<0.0001), while TNF-alpha
increased significantly from N1 to N5 and declined thereafter. MS
infinity IL-1 beta and IL-6, but not MS infinity TNF-alpha, mere
significantly higher than those of controls (P<0.0001). IL-1 beta values
depended on the mode of delivery. In conclusion, the increased
concentrations of IL-1 beta, IL-6 and TNF-alpha during the perinatal
period might suggest their involvement in an inflammation-like process
during normal parturition, and reflect also a newborn immune response to
the stress of delivery and environmental changes.
ER -