TY - JOUR
TI - Lectin histochemistry of laryngeal squamous cell carcinomas
AU - Tsambaos, D
AU - Pasmatzi, E
AU - Manolopoulos, L
AU - Kapranos, N and
AU - Goumas, P
AU - Adamopoulos, G
JO - Otolaryngology - Head and Neck Surgery
PY - 1998
VL - 118
TODO - 6
SP - 886-891
PB - Mosby Year Book Inc
SN - 0194-5998, 1097-6817
TODO - 10.1016/S0194-5998(98)70292-X
TODO - null
TODO - A panel of five biotinylated lectins was applied to study the presence
and distribution of membrane carbohydrate residues in the normal
laryngeal epithelium and in laryngeal squamous cell carcinomas (SCCs) of
86 patients with the avidin-biotin peroxidase complex technique. The
lectin-binding pattern of well-differentiated SCCs was comparable to
that of the spinous cells of the normal laryngeal epithelium. In the
less differentiated SCCs, staining of the keratinocyte plasma membrane
with lectins was either reduced or absent, indicating a decline in the
glycosylation of cell surface glycoconjugates, The lectins applied here
could be used in the rapid assessment of less-differentiated areas
within a laryngeal SCC, but they cannot be regarded as reliable markers
of laryngeal keratinocytes undergoing malignant transformation.
ER -