TY - JOUR
TI - Comparative in vitro and in vivo efficacy of roxithromycin and
erythromycin against a strain of methicillin-susceptible Staphylococcus
epidermidis
AU - Danias, PG
AU - Chalevelakis, G
AU - Mylonakis, EE
AU - Argyropoulou, A and
AU - Paniara, O
AU - Saroglou, G
AU - Raptis, SA
JO - Diagnostic Microbiology and Infectious Disease
PY - 1998
VL - 32
TODO - 1
SP - 51-54
PB - EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
SN - 0732-8893
TODO - 10.1016/S0732-8893(98)00059-5
TODO - null
TODO - The in vitro and in vivo efficacy of roxithromycin was compared with
that of erythromycin, against a methicillin-susceptible strain of
Staphylococcus epidermidis. We performed standard in vitro testing (MIC,
MBC, and time-kill kinetics) for roxithromycin, erythromycin, and
rifampin. Both macrolides were bacteriostatic in vitro. There was no
significant difference in microbial survival between erythromycin and
roxithromycin groups in the time-kill kinetics (p = 0.3). For the in
vivo experiments, using the rabbit experimental endocarditis model,
roxithromycin was found to be inferior to erythromycin in decreasing the
microbial burden of the endocardial vegetations (p < 0.05). Rifampin was
highly effective, both in vitro and in vivo. In conclusion, the efficacy
of roxithromycin was poor and inferior to erythromycin against a strain
of methicillin-susceptible S. epidermidis. (C) 1998 Elsevier Science
Inc.
ER -