TY - JOUR
TI - Differential alterations in basal and D-amphetamine-induced behavioural
pattern following 6-OHDA or ibotenic acid lesions into the dorsal
striatum
AU - Antoniou, K
AU - Papadopoulou-Daifotis, Z
AU - Kafetzopoulos, E
JO - BEHAVIOURAL BRAIN RESEARCH
PY - 1998
VL - 97
TODO - 1-2
SP - 13-28
PB - ELSEVIER SCIENCE BV
SN - 0166-4328
TODO - 10.1016/S0166-4328(98)00014-X
TODO - D-amphetamine; ibotenic acid; 6-OHDA; dorsal striatum; behavioural
pattern; rat
TODO - It is well known that the corpus striatum is related to the sterotyped
activation induced by several psychostimulants. In this study we
analyzed the effects of 6-OHDA, in comparison with those of ibotenic
acid lesions, into the dorsal striatum, on the behavioural pattern
induced by saline or D-amphetamine treatment. A computerized technique
for recording the animal motor activity was developed in order to define
in a detailed way the behavioural profile in lesioned and sham-operated
rats induced by the saline or D-amphetamine treatment. A 6-OHDA lesion
into the dorsal striatum modified the basal behavioural pattern which
was mainly characterized by reduced motor activation while ibotenic acid
lesion affected the structure of the basal behavioral pattern.
D-Amphetamine administration in 6-OHDA lesioned rats induced a
behavioural stimulation, but a decreased motor and stereotyped
activation was observed compared to the sham-operated animals treated
with D-amphetamine. In contrast, D-amphetamine administration in the
ibotenic acid-lesioned rats induced a motor and stereotyped activity
which was not reduced compared to that seen after D-amphetamine
treatment in sham-operated rats. These results suggest that these two
types of lesion induced differential effects on the behavioural pattern
either after saline or after D-amphelamine administration. Dopaminergic
neurotransmission in the dorsal striatum plays a permissive role on the
emergence of the behavioural responses, while the dorsal striatum
circuitry plays a crucial role on the organization of the behavioural
pattern. In addition, dopaminergic activity in this structure serves a
primary control in the D-amphetamine-elicited motor activation or
stereotypy, while the striatal structure is involved in the shaping of
the D-amphetamine behavioural pattern. (C) 1998 Elsevier Science B.V.
All rights reserved.
ER -