TY - JOUR
TI - Human leukocyte antigens as genetic markers in colorectal carcinoma
AU - Chatzipetrou, MA
AU - Tarassi, KE
AU - Konstadoulakis, MM
AU - Pappas, HE
AU - and Zafirellis, KD
AU - Athanassiades, TE
AU - Papadopoulos, SA and
AU - Panousopoulos, DG
AU - Golematis, BC
AU - Papasteriades, CA
JO - Diseases of the Colon & Rectum
PY - 1999
VL - 42
TODO - 1
SP - 66-70
PB - Lippincott, Williams & Wilkins
SN - 0012-3706, 1530-0358
TODO - 10.1007/BF02235184
TODO - colorectal carcinoma; human leukocyte antigens; genetic markers
TODO - PURPOSE: Similar to findings obtained for most carcinomas, the
pathogenesis of colorectal cancer is considered to be multifactorial.
There is strong evidence for an inherited, genetic predisposition to
disease in patients with familial adenomatous polyposis and hereditary
nonpolyposis colorectal cancer. There is still debate, however, about
the contribution of genetic factors to the pathogenesis of sporadic
colorectal cancer. The present study was undertaken to search for human
leukocyte antigen associations in a group of patients with colorectal
cancer and to correlate the findings with both the histology of the
disease and family history. SUBJECTS AND METHODS: The allele frequencies
of serologically defined human leukocyte antigen class I and II antigens
were studied in 101 patients with a recent, histologically confirmed
diagnosis of colorectal cancer. AU individuals in this study were
unrelated to each other. After surgical treatment, all patients were
grouped according to the stage (Dukes Stages A, B, C, and D),
differentiation (Grades 1, 2, and 3), and the site of the tumor.
Patients were also classified with regard to family history for
colorectal cancer. The results obtained for human leukocyte antigen
frequencies were compared with those of 105 healthy control subjects
(control group). RESULTS: An increased frequency of human leukocyte
antigen-B18 (27.72 vs. 14.28 percent; P < 0.025; odds ratio = 2.3) and
of human leukocyte antigen-DQ5 (43.56 vs. 22.5 percent; P < 0.01; odds
ratio = 2.65) was observed for patients with colorectal cancer vs.
control subjects, respectively. In addition, human leukocyte antigen-B18
was present with increased frequency (30.76 percent; P < 0.05; odds
ratio = 2.66; and 26.67 percent; P < 0.05; odds ratio = 2.18) among
patients with rectal and colon carcinoma, respectively. A higher
frequency of human leukocyte antigen-DQ5 (45.33 percent; P < 0.01; odds
ratio = 2.84) was observed among patients with colon carcinoma.
Remarkably, human leukocyte antigen-DQ5 (50 vs. 22.5 percent; P < 0.05;
odds ratio = 3.43) and human leukocyte antigen-Al (41.66 vs. 12.38
percent; P < 0.01; odds ratio = 5.05) were found to be strongly
associated with a family history of colorectal cancer. CONCLUSION: The
observation of specific human leukocyte antigen associations with
particular subsets of colorectal cancer strongly suggests that genetic
susceptibility for the development of colorectal cancer exists. Although
the multifactorial pathogenesis of colorectal cancer must be considered,
human leukocyte antigens may have useful predictive and diagnostic
value.
ER -