TY - JOUR
TI - Increased resistance to activated protein C and factor V Leiden in
recurrent abortions. Review of other hypercoagulability factors
AU - Hatzis, T.
AU - Cardaniakis, E.
AU - Drivalas, E.
AU - Makatsoris, K. and
AU - Bevan, D.
AU - Pantos, C.
AU - Malliopoulou, V.
AU - Tsagaris, N. and
AU - Kreatsa, O.
AU - Antoniadi, T.
AU - Petersen, M. B.
AU - Karageorgiou, H.
AU - and Mantouvalos, H.
JO - The European Journal of Contraception and Reproductive Health Care
PY - 1999
VL - 4
TODO - 3
SP - 135-144
PB - TAYLOR & FRANCIS LTD LONDON
SN - 1362-5187, 1473-0782
TODO - 10.3109/13625189909040808
TODO - Recurrent abortions; Thrombophilia; Increased APC-R; Factor V Leiden
TODO - Objective To evaluate hereditary and acquired hemostatic abnormalities
associated with recurrent spontaneous early (first-trimester) abortions.
Method A group of 56 Greek women with two or more unexplained primary
spontaneous abortions, and a reference group of 148 women without a
history of recurrent abortions, were screened for hypercoagulability. A
randomly selected population of first-trimester pregnant women was also
chosen for factor V Leiden genetic screening.
Results A total of 21% of the women with recurrent abortions, compared
with 12% of the reference group, showed increased activated protein C
resistance. Fourteen per cent had positive lupus anticoagulant, compared
with 11.5% of the reference group. For the rest of the parameters,
there was no difference between the two groups. Of 22 women studied for
factor V Leiden, one was homozygous and one was heterozygous. Results
were compared using Fisher’s exact test and two-tailed Student’s t
tests.
Conclusions Increased activated protein C resistance appears to be an
important factor in women with recurrent abortions. These data indicate
the need for routine investigation of activated protein C resistance in
women with recurrent abortions.
ER -