TY - JOUR
TI - Double biochemical modulation of 5-fluorouracil by methotrexate and
folinic acid for the treatment of advanced colorectal cancer
AU - Polyzos, A
AU - Tsavaris, N
AU - Kosmas, C
AU - Petrikos, G and
AU - Stamatiadis, D
AU - Kalahanis, N
AU - Giannopoulos, A
AU - Karatzas, G and
AU - Sfikakis, PP
JO - Clinical Drug Investigation
PY - 1999
VL - 17
TODO - 2
SP - 83-88
PB - Adis International Ltd
SN - 1173-2563
TODO - 10.2165/00044011-199917020-00001
TODO - null
TODO - Objective: We investigated the double biochemical modulation of
5-fluorouracil (5-FU) by methotrexate (MTX) and folinic acid (FA) for
the treatment of 65 patients with advanced colorectal cancer. In
particular, we studied the response and toxicity of the regimen.
Methods: A combination of MTX 130 mg/m(2) intravenously at day 0,
followed 24 hours later by FA orally as MTX rescue, and FA 300 mg/m2
intravenously daily (days 1 to 4) followed by 5-FU 500 mg/m(2)
intravenously daily (days 1 to 4) was administered.
Results: Objective response was achieved by 23 patients, with three
complete and 20 partial responses [35%: 95% confidence interval (CI)
23 to 48%]. Median survival of the group was 12 months (range 6 to 36
months).
Conclusion: According to these results, double biochemical modulation of
5-FU : with MTX and FA led to a significantly higher response rate
followed by considerable toxicity.
ER -