TY - JOUR
TI - Impact of body mass on autonomic function in persons with type 2
diabetes
AU - Tentolouris, N
AU - Grapsas, E
AU - Stambulis, E
AU - Papageorgiou, K and
AU - Katsilambros, N
JO - Diabetes Research and Clinical Practice
PY - 1999
VL - 46
TODO - 1
SP - 29-33
PB - ELSEVIER SCI IRELAND LTD
SN - 0168-8227
TODO - 10.1016/S0168-8227(99)00069-8
TODO - autonomic neuropathy; type 2 diabetes mellitus; obesity
TODO - The aim of this study was to investigate the influence of body mass on
autonomic nerve function in persons with type 2 diabetes. Towards this
aim we studied two groups of diabetic persons. Group 1: n = 30 lean
(mean age 57.2 +/- 12.5 years, body mass index (BMI) 22.5 +/- 1.8
kg/m(2)]. Group 2: n = 35 overweight and obese (age 52.3 +/- 10.3 years,
BMI 28.8 +/- 3.2 kg/m(2)). Autonomic neuropathy (DAN) was assessed using
the battery of the five classical tests. DAN was diagnosed when at least
two of the five tests were abnormal. Abnormalities of the heart rate
based tests were considered as indication of parasympathetic and of
blood pressure changes as indication of sympathetic dysfunction. The
prevalence rates of DAN were not different between group 2 and group 1
(54.2 and 53.3%, respectively, P = 0.54). The same was valid for the
rates of parasympathetic and sympathetic dysfunction in the studied
groups (51.4 and 53.3% (P = 0.87) in group 2 and 34.2 and 33.3% (P =
0.93) in group 1, respectively). When the values of the arithmetic
expression of each single autonomic function test were compared, no
significant difference could be shown between the studied groups. In
addition, no significant correlation was found between BMI and indices
of DAN. These data indicate that moderate increase of body mass does not
affect autonomic function in persons with type 2 diabetes. (C) 1999
Elsevier Science Ireland Ltd. All rights reserved.
ER -