TY - JOUR
TI - Kinetic analysis of parallel reactions, the initial reactant of which
presents with two interconvertible isomeric forms (hydrolysis and
hydroxylaminolysis of 6-phosphogluconolactone)
AU - Rakitzis, ET
AU - Papandreou, P
JO - Journal of Theoretical Biology
PY - 1999
VL - 200
TODO - 4
SP - 427-434
PB - Academic Press Ltd, London
SN - 0022-5193, 1095-8541
TODO - 10.1006/jtbi.1999.1006
TODO - null
TODO - A mathematical treatment is presented of two parallel reactions each one
of which can be described by the sum of two exponential functions of
time. The two simplest reaction models consistent with this requirement
are presented, and are shown to be described by a second-order
non-homogeneous differential equation with constant coefficients.
Solutions of this equation in closed form are given, and it is shown
that, as is the case with pairs of parallel first-order reactions,
description of the time course of one of the two reactions yields a
complete description of the time course of the other reaction.
Hypothetical cases, consistent with the reaction models presented, are
given and are compared with experimental results, obtained on the
parallel reactions of 6-phosphogluconolactone hydrolysis and
hydroxylaminolysis. Results are compatible with the existence of
enzymically generated 6-phosphogluconolactone in two interconvertible
isomeric forms. (C) 1999 Academic Press.
ER -