TY - JOUR
TI - Elevated plasma immunoreactive leptin levels preexist in healthy
offspring of patients with essential hypertension
AU - Makris, TK
AU - Stavroulakis, GA
AU - Krespi, PG
AU - Hatzizacharias, AN
AU - and Kyriaki, DK
AU - Chronakis, EV
AU - Anastasiadis, G
AU - Triposkiadis,
AU - FK
AU - Kyriakidis, MK
JO - American Heart Journal
PY - 1999
VL - 138
TODO - 5, 1
SP - 922-925
PB - Mosby Year Book Inc
SN - 0002-8703, 1097-6744
TODO - 10.1016/S0002-8703(99)70018-9
TODO - null
TODO - Background Plasma leptin levels and plasma insulin levels have been
found to be elevated in patients with essential hypertension (EH) and
have been suggested to be components of the metabolic syndrome.
Increased heart rate (HR) may predict the development of EH in normal or
borderline-hypertensive individuals. The aim of our study was to test
the hypothesis that elevated plasma leptin and insulin levels as well as
systolic blood pressure (SBP) and diastolic blood pressure (DBP) and
increased resting HR preexist in the healthy offspring of patients with
EH.
Methods and Results Twenty-six (12 male, 14 female) healthy offspring of
hypertensive patients, mean age 16 +/- 2.5 years and body mass index
(BMI) of 21.5 +/- 2.8 kg/m(2) (group A), and 30 (14 mole, 16 female)
healthy offspring of normotensive patients, mean age 17 +/- 2.3 years
and BMI of 21.9 +/- 2.4 kg/m(2) (group B), were studied. (The two groups
were matched for sex, age, and BMI). Mean SEP, DBP, resting HR, plasma
leptin, and plasma insulin levels (radioimmunoassay method) were
determined in the whole study population. Mean SEP, DBP, and resting HR
were significantly higher in group A than in group B (120 +/- 12 vs 112
+/- 9.5 mm Hg, 77 +/- 9 vs 72 +/- 7 mm Hg, 79 +/- 8 vs 75 +/- 5
beats/min, P < .01, P < .05, and P < .05, respectively). Plasma leptin
and insulin levels were significantly higher in group A than in group B
(9 +/- 5.06 vs 5.6 +/- 2.5 ng/ml and 20.11 +/- 11.3 vs 14.8 +/- 5.2 mu
IU/ml, P < .01 and P < .05, respectively).
Conclusions Our findings support the hypothesis that hyperleptinemia,
hyperinsulinemia, and elevated blood pressure and resting HR preexist in
the healthy offspring of patients with EH.
ER -