TY - JOUR
TI - Indium-111 monoclonal antimyosin cardiac scintigraphy in men with
idiopathic dilated cardiomyopathy
AU - Nanas, JN
AU - Margari, ZJ
AU - Lekakis, JP
AU - Alexopoulos, GE and
AU - Prassopoulos, V
AU - Agapitos, EV
AU - Toumanidis, ST
AU - Anastasiou-Nana,
AU - MI
AU - Kostamis, P
AU - Stamatelopoulos, SF
JO - AMERICAN JOURNAL OF CARDIOLOGY
PY - 2000
VL - 85
TODO - 2
SP - 214-220
PB - EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
SN - 0002-9149
TODO - 10.1016/S0002-9149(99)00641-4
TODO - null
TODO - This study examined the prognostic value and the evolution of the
heart-to-lung ratio of monoclonal antimyosin antibody (MAA) uptake in
patients with a diagnosis of idiopathic dilated cardiomyopathy (IDC).
Uptake of indium-111-labeled MAA occurs when the myocytes become
irreversibly damaged. The study included 29 men with IDC followed up For
3 years. The diagnosis was verified by endomyocardial biopsy in all
patients. Patients who survived beyond 1 year were restudied. Baseline
heart-to-lung ratio st MAA was 1.74 +/- 0.22. Multivariate Cox
regression analysis revealed that MAA and New York Heart Association
class were independent predictors of late mortality, with a hazard ratio
of 4.4 (95% confidence interval 1.1 to 17.9, p = 0.036) and 7.5 (95%
confidence interval 2.0 to 28.4, p 0.003), respectively, when
heart-to-lung ratio of MAA uptake was >1.74 and New York Heart
Association class was >II. When these patients were divided into those
with chronic IDC (group I [n = 19]) and those with subacute IDC (group
II [n = 10]), baseline heart-to-lung ratio was 1.7 +/- 0.2 and 1.86
+/- 0.25, respectively tp = NS). In the surviving patients, on restudy,
the heart-to-lung ratio of MAA uptake was unchanged in group I (1.64 +/-
0.20, p = NS), bur had decreased to the level of group 1 (1.66 +/- 0.2 1
[p = 0.008]) in group II. Thus, men with IDC and a high heart-to-lung
ratio of MAA uptake have a worse long-term prognosis than patients with
ct lower ratio. The heart-to-lung ratio of MAA decreases comparably over
time in subacute IDC and remains stable in chronic IDC. (C) 2000 by
Excerpta Medica, Inc.
ER -