TY - JOUR
TI - Acute promyelocytic leukemia relapsing into FAB-M2 acute myeloid
leukemia with trisomy 8
AU - Stavroyianni, N
AU - Yataganas, X
AU - Abazis, D
AU - Pangalos, C and
AU - Meletis, J
JO - CANCER GENETICS AND CYTOGENETICS
PY - 2000
VL - 117
TODO - 1
SP - 82-83
PB - EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
SN - 0165-4608
TODO - 10.1016/S0165-4608(99)00132-6
TODO - null
TODO - Acute promyelocytic leukemia was diagnosed in a 48-year-old man; the
karyotype was normal, whereas reverse transcriptase polymerase chain
reaction (RT-PCR) analysis identified PML/RAR alpha chimeric transcripts
of the bcr3 type. Rather unexpectedly, the patient did not respond to
all-trans retinoic acid administration; he attained complete remission
with conventional chemotherapy and became PML/RAR alpha negative. Two
years later while PML/RAR alpha negative nn RT-PCR he presented with
thrombocytopenia. Bone marrow examination was compatible with
myelodysplasia of the RAEB type; the karyotype was normal. Then, after
10 months, he developed overt acute myeloid leukemia with PML/RAR alpha
negative, French-American-British MZ blasts; karyotypic analysis
revealed mosaicism for trisomy 8. (C) Elsevier Science Inc., 2000. All
rights reserved.
ER -