TY - JOUR
TI - Serum Lp(a) lipoprotein levels in patients with atherosclerotic
occlusive disease of the lower extremities
AU - Dionyssiou-Asteriou, A
AU - Papastamatiou, M
AU - Vatalas, IA and
AU - Bastounis, E
JO - European Journal of Vascular and Endovascular Surgery
PY - 2000
VL - 20
TODO - 1
SP - 57-60
PB - W B SAUNDERS CO LTD
SN - 1078-5884, 1532-2165
TODO - 10.1053/ejvs.2000.1100
TODO - lipoprotein (a) (Lp(a)); high density lipoprotein (HDL); atherosclerotic
occlusive disease; peripheral vascular disease (PVD)
TODO - Objective: to evaluate the association between Lp(a) lipoprotein levels,
other serum lipids and the presence of lower limb atherosclerotic
occlusive disease.
Materials and methods: angiographic findings in 36 patients were related
to serum Lp(a). Total cholesterol, triglycerides, LDL-cholesterol,
HDL-cholesterol and Lp(a) levels were compared with those of 73 age- and
sex-matched healthy controls.
Results: atheromatous lesions were localised in the femoropopliteal
(approximate to 60%) and aortoiliac (approximate to 40%) segments. The
number of stenosed arteries was greater than or equal to 2 and the range
of stenosis severity was between 40% and 100%. There was a significant
increase in serum Lp(a) (p = 0.000001) and a decrease in serum HDL (p =
0.000009) levels in patients compared to controls. No difference was
observed in total cholesterol, LDL-cholesterol or triglyceride. However,
the ratio of total cholesterol/HDL-cholesterol was significantly higher
(p = 0.005) in patients.
Conclusions: a dyslipidaemic serum profile, characterised by increased
Lp(a) levels and decreased HDL-cholesterol levels, is associated with
atherosclerotic occlusive disease of the lower extremities.
ER -