TY - JOUR
TI - Study of the Trp(64)Arg Polymorphism of the beta(3)-adrenergic receptor
in Greek women with gestational diabetes
AU - Alevizaki, M
AU - Thalassinou, L
AU - Grigorakis, SI
AU - Philippou, G and
AU - Lili, K
AU - Souvatzoglou, A
AU - Anastasiou, E
JO - DIABETES CARE
PY - 2000
VL - 23
TODO - 8
SP - 1079-1083
PB - AMER DIABETES ASSOC
SN - 0149-5992
TODO - 10.2337/diacare.23.8.1079
TODO - null
TODO - OBJECTIVE - This study assessed whether the Trp(64)Arg polymorphism of
the beta(3)-adrenergic receptor (beta(3)-AR), which has been associated
with obesity, insulin resistance, weight gain, and earlier onset of type
2 diabetes, is more frequent in women who develop gestational diabetes
mellitus (GDM) or whether it is associated with weight gain during
pregnancy.
RESEARCH DESIGN AND METHODS - A total of 311 Greek pregnant women (180
with GDM and 131 without GDM [control]) who underwent a 100-g oral
glucose tolerance test (OGTT) in the third trimester of pregnancy were
genotyped for the beta(3)-AR Arg(64) polymorphism. Insulin levels were
also determined during the OGTT.
RESULTS - The frequency of Trp(64)Arg heterozygotes in this population
was similar to 7% and was similar in the GDM and control groups (6.7
vs. 6.9%) as well as in the obese (BMI greater than or equal to 27
kg/m(2)) and the nonobese (6.3 vs. 6.8%) subgroups. In the GDM group,
BMI, fasting insulin resistance index, and diastolic blood pressure were
significantly higher in Trp(64)Arg carriers; these differences were no
longer observed when obesity was considered. In the 4 subgroups (control
Trp(64)Trp and Trp(64)Arg and GDM Trp(64)Trp and Trp(64)Arg), a highly
significant trend was evident of an increase in the percentage of
subjects with shorter height.
CONCLUSIONS - The frequency of the Arg(64) allele in Greek pregnant
women is relatively rare compared with other ethnic groups and is
probably not related to the development of GDM or obesity. The observed
tendency for shorter body height in Arg(64) carriers merits further
evaluation in larger population samples.
ER -