TY - JOUR
TI - Treatment of experimental osteomyelitis caused by methicillin-resistant
Staphylococcus aureus with a biodegradable system of lactic acid polymer
releasing pefloxacin
AU - Kanellakopoulou, K
AU - Galanakis, N
AU - Giamarellos-Bourboulis, EJ and
AU - Rifiotis, C
AU - Papakostas, K
AU - Andreopoulos, A
AU - Dounis, E and
AU - Karagianakos, P
AU - Giamarellou, H
JO - The Journal of antimicrobial chemotherapy
PY - 2000
VL - 46
TODO - 2
SP - 311-314
PB - Oxford University Press
SN - null
TODO - 10.1093/jac/46.2.311
TODO - null
TODO - A novel biodegradable system of D-,L-dilactide delivering pefloxacin was
implanted in 104 rabbits with experimental osteomyelitis caused by
methicillin-resistant Staphylococcus aureus (MRSA), 26 serving as
controls. Animals were killed on each third day and viable bacterial
counts and levels of pefloxacin in bone tissue were determined. A 99.9%
decrease in viable count of bacteria was achieved by day 12 and complete
bacterial eradication on day 33. Pefloxacin was released gradually,
reaching its peak on day 15 at levels 100 times the MIC of pefloxacin
for MRSA. The biodegradable system described may have a future role in
the therapeutic approach to osteomyelitis.
ER -