TY - JOUR
TI - Leptin serum levels in cachectic heart failure patients - Relationship
with tumor necrosis factor-alpha system
AU - Filippatos, GS
AU - Tsilias, K
AU - Venetsanou, K
AU - Karambinos, E and
AU - Manolatos, D
AU - Kranidis, A
AU - Antonellis, J
AU - Kardaras, F and
AU - Anthopoulos, L
AU - Baltopoulos, G
JO - International Journal of Cardiology
PY - 2000
VL - 76
TODO - 2-3
SP - 117-122
PB - Elsevier Ireland Ltd
SN - 0167-5273
TODO - 10.1016/S0167-5273(00)00397-1
TODO - carchiac cachexia; leptin; tumor necrosis factor-alpha
TODO - Cachexia is a strong predictor for mortality in patients with congestive
heart failure. To investigate the role of leptin and regulators of
apoptosis in cardiac cachexia we compared leptin concentrations and
their relation to the TNF system, interleukin 1-beta (TL-1b), and
soluble Fas in patients with heart failure with and without cachexia.
Patients with cardiac cachexia have increased levels of interleukin-1b
compared to non-cachectic heart failure patients
[mean(S.E.)=1.11(0.62) vs. 0.02(0.02), P=0.01] and decreased
concentrations of leptin [10.79(3.93) vs. 23.24 (8.35), P=0.1]. Leptin
levels correlate with TNF-RI in cachectic heart failure patients
(r=0.58, P=0.018). The TNF-RI levels were also correlated with Fas, both
in all the patients taken together (r=0.5, P=0.006) and in those with
cachexia (r=0.52, P=0.036). Our data indicate that more prospective
studies are needed to clarify the role of leptin in the pathophysiology
of heart failure cachexia. (C) 2000 Elsevier Science Ireland Ltd. All
rights reserved.
ER -