TY - JOUR
TI - Human papillomavirus infection of non-melanoma skin cancers in
immunocompetent hosts
AU - Biliris, KA
AU - Koumantakis, E
AU - Dokianakis, DN
AU - Sourvinos, G and
AU - Spandidos, DA
JO - Cancer Letter
PY - 2000
VL - 161
TODO - 1
SP - 83-88
PB - ELSEVIER SCI IRELAND LTD
SN - null
TODO - 10.1016/S0304-3835(00)00596-6
TODO - human papillomavirus; non-melanoma skin carcinoma; immunocompetence;
polymerase chain reaction
TODO - Human papilloma viruses (HPVs) consist of more than 70 different types
and are known to be associated with numerous malignant tumors, including
carcinomas of the mucosal and cutaneous epithelium. Non-melanoma skin
carcinoma (NMSC) is the most frequently occurring malignancy worldwide
in the Caucasian population. Most studies examining the involvement of
papillomaviruses in the development of cutaneous carcinomas have been
performed on lesions from patients with epidermodysplasia verruciformis
or from immunosuppressed patients. Our specimens were obtained from 108
immunocompetent patients with benign and malignant skin lesions, and
HPVs were detected in 27%. HPV 8 and HPV 18 were the most frequent
types (62 and 48%, respectively). Our results suggest that HPVs,
particularly the oncogenic potential of certain types such as HPV 8, 18,
and 5 could contribute to the development of NMSCs. (C) 2000 Elsevier
Science Ireland Ltd. All rights reserved.
ER -