TY - JOUR
TI - Transcriptomic similarities and differences in host response between SARS-CoV-2 and other viral infections
AU - Thair, S.A.
AU - He, Y.D.
AU - Hasin-Brumshtein, Y.
AU - Sakaram, S.
AU - Pandya, R.
AU - Toh, J.
AU - Rawling, D.
AU - Remmel, M.
AU - Coyle, S.
AU - Dalekos, G.N.
AU - Koutsodimitropoulos, I.
AU - Vlachogianni, G.
AU - Gkeka, E.
AU - Karakike, E.
AU - Damoraki, G.
AU - Antonakos, N.
AU - Khatri, P.
AU - Giamarellos-Bourboulis, E.J.
AU - Sweeney, T.E.
JO - ISCIENCE
PY - 2021
VL - 24
TODO - 1
SP - null
PB - W B SAUNDERS CO-ELSEVIER INC
SN - null
TODO - 10.1016/j.isci.2020.101947
TODO - null
TODO - The pandemic 2019 novel coronavirus disease (COVID-19) shares certain clinical characteristics with other acute viral infections. We studied the whole-blood transcriptomic host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using RNAseq from 24 healthy controls and 62 prospectively enrolled patients with COVID-19. We then compared these data to non-COVID-19 viral infections, curated from 23 independent studies profiling 1,855 blood samples covering six viruses (influenza, respiratory syncytial virus (RSV), human rhinovirus (HRV), severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1), Ebola, dengue). We show gene expression changes in COVID-19 versus non-COVID-19 viral infections are highly correlated (r = 0.74, p < 0.001). However, we also found 416 genes specific to COVID-19. Inspection of top genes revealed dynamic immune evasion and counter host responses specific to COVID-19. Statistical deconvolution of cell proportions maps many cell type proportions concordantly shifting. Discordantly increased in COVID-19 were CD56bright natural killer cells and M2 macrophages. The concordant and discordant responses mapped out here provide a window to explore the pathophysiology of the host response to SARS-CoV-2. © 2020 The Authors
Molecular Biology; Immunology: Bioinformatics; Transcriptomics © 2020 The Authors
ER -