TY - JOUR
TI - Maternal and neonatal characteristics and outcomes of covid-19 in pregnancy: An overview of systematic reviews
AU - Papapanou, M.
AU - Papaioannou, M.
AU - Petta, A.
AU - Routsi, E.
AU - Farmaki, M.
AU - Vlahos, N.
AU - Siristatidis, C.
JO - International Journal of Environmental Research and Public Health
PY - 2021
VL - 18
TODO - 2
SP - 1-20
PB - MDPI AG
SN - 1660-4601
TODO - 10.3390/ijerph18020596
TODO - COVID-19;  maternal health;  mental disorder;  mortality;  pregnancy;  vertical transmission;  womens health, anxiety;  artificial ventilation;  cesarean section;  coronavirus disease 2019;  female;  gestational age;  human;  intensive care unit;  labor induction;  maternal mortality;  obstetric delivery;  pregnancy;  premature fetus membrane rupture;  premature labor;  quality control;  Review;  Severe acute respiratory syndrome coronavirus 2;  spontaneous abortion;  stillbirth;  systematic review;  vertical transmission;  adult;  epidemiology;  newborn;  pandemic;  pregnancy;  pregnancy complication;  pregnancy outcome;  prematurity;  prevention and control;  virology, SARS coronavirus, Adult;  COVID-19;  Female;  Humans;  Infant, Newborn;  Infectious Disease Transmission, Vertical;  Pandemics;  Pregnancy;  Pregnancy Complications, Infectious;  Pregnancy Outcome;  Premature Birth;  SARS-CoV-2
TODO - (1) Background: A considerable number of systematic reviews, with substantial heteroge-neity regarding their methods and included populations, on the impact of COVID-19 on infected pregnant women and their neonates, has emerged. The aim was to describe the obstetric-perinatal and neonatal outcome of infected pregnant women and their newborns during the COVID-19 pan-demic; (2) Methods: Three bibliographical databases were searched (last search: September 10, 2020). Quality assessment was performed using the AMSTAR-2 tool. Primary outcomes included mode of delivery, preterm delivery/labor, premature rupture of membranes (PROM/pPROM) and abor-tions/miscarriages. Outcomes were mainly presented as ranges. A separate analysis, including only moderate and high-quality systematic reviews, was also conducted. The protocol was registered with PROSPERO (CRD42020214447); (3) Results: Thirty-nine reviews were analyzed. Reported rates, regarding both preterm and term gestations, varied between 52.3 and 95.8% for cesarean sections; 4.2–44.7% for vaginal deliveries; 14.3–63.8% specifically for preterm deliveries and 22.7–32.2% for preterm labor; 5.3–12.7% for PROM and 6.4–16.1% for pPROM. Maternal anxiety for potential fetal infection contributed to abortion decisions, while SARS-CoV-2-related miscarriages could not be excluded. Maternal ICU admission and mechanical ventilation rates were 3–28.5% and 1.4–12%, respectively. Maternal mortality rate was <2%, while stillbirth, neonatal ICU admission and mortality rates were <2.5%, 3.1–76.9% and <3%, respectively. Neonatal PCR positivity rates ranged between 1.6% and 10%. After accounting for quality of studies, ranges of our primary outcomes re-mained almost unchanged, while among our secondary outcomes, maternal ICU admission (3–10%) and mechanical ventilation rates (1.4–5.5%) were found to be relatively lower; (4) Conclusions: In-creased rates of cesarean sections and preterm birth rates were found, with iatrogenic reasons potentially involved. In cases of symptomatic women with confirmed infection, high maternal and neonatal ICU admission rates should raise some concerns. The probability of vertical transmission cannot be excluded. Further original studies on women from all trimesters are warranted. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
ER -