TY - JOUR
TI - Associations between fine and coarse particles and mortality in Mediterranean cities: Results from the MED-PARTICLES project
AU - Samoli, E.
AU - Stafoggia, M.
AU - Rodopoulou, S.
AU - Ostro, B.
AU - Declercq, C.
AU - Alessandrini, E.
AU - Díaz, J.
AU - Karanasiou, A.
AU - Kelessis, A.G.
AU - Tertre, A.L.
AU - Pandolfi, P.
AU - Randi, G.
AU - Scarinzi, C.
AU - Zauli-Sajani, S.
AU - Katsouyanni, K.
AU - Forastiere, F.
AU - Alessandrini, E.
AU - Angelini, P.
AU - Berti, G.
AU - Bisanti, L.
AU - Cadum, E.
AU - Catrambone, M.
AU - Chiusolo, M.
AU - Davoli, M.
AU - de’ Donato, F.
AU - Demaria, M.
AU - Gandini, M.
AU - Grosa, M.
AU - Faustini, A.
AU - Ferrari, S.
AU - Forastiere, F.
AU - Pandolfi, P.
AU - Pelosini, R.
AU - Perrino, C.
AU - Pietrodangelo, A.
AU - Pizzi, L.
AU - Poluzzi, V.
AU - Priod, G.
AU - Randi, G.
AU - Ranzi, A.
AU - Rowinski, M.
AU - Scarinzi, C.
AU - Stivanello, E.
AU - Zauli-Sajani, S.
AU - Dimakopoulou, K.
AU - Elefteriadis, K.
AU - Katsouyanni, K.
AU - G.Kelessis, A.
AU - Maggos, T.
AU - Michalopoulos, N.
AU - Pateraki, S.
AU - Petrakakis, M.
AU - Rodopoulou, S.
AU - Samoli, E.
AU - Sypsa, V.
AU - Agis, D.
AU - Alguacil, J.
AU - Artiñano, B.
AU - Barrera-Gómez, J.
AU - Basagaña, X.
AU - de la Rosa, J.
AU - Diaz, J.
AU - Fernandez, R.
AU - Jacquemin, B.
AU - Linares, C.
AU - Ostro, B.
AU - Pérez, N.
AU - Pey, J.
AU - Querol, X.
AU - Sanchez, AM.
AU - Sunyer, J.
AU - Tobias, A.
AU - Bidondo, M.
AU - Declercq, C.
AU - Le Tertre, A.
AU - Lozano, P.
AU - Medina, S.
AU - Pascal, L.
AU - Pascal, M.
AU - MED-PARTICLES Study Group:
JO - Environmental Health Perspectives
PY - 2013
VL - 121
TODO - 8
SP - 932-938
PB - Public Health Services, US Dept of Health and Human Services
SN - 0091-6765, 1552-9924
TODO - 10.1289/ehp.1206124
TODO - aged;  article;  cardiovascular mortality;  disease association;  environmental exposure;  female;  human;  influenza;  major clinical study;  male;  mortality;  particulate matter;  priority journal;  respiratory failure;  seasonal variation;  Southern Europe;  statistical model;  temperature;  weather, Aged;  Air Pollutants;  Case-Control Studies;  Cities;  Cross-Over Studies;  Environmental Exposure;  Environmental Monitoring;  Female;  Humans;  Male;  Mediterranean Region;  Models, Theoretical;  Mortality;  Particle Size;  Particulate Matter;  Seasons
TODO - Background: Few studies have investigated the independent health effects of different size fractions of particulate matter (PM) in multiple locations, especially in Europe. Objectives: We estimated the short-term effects of PM with aerodynamic diameter ≤ ; 10; μm (PM10), ≤ 2.5; μm (PM2.5), and between 2.5 and 10; μm (PM2.5-10) on all-cause, cardiovascular, and respiratory mortality in 10 European Mediterranean metropolitan areas within the MED-PARTICLES project. Methods: We analyzed data from each city using Poisson regression models, and combined city-specific estimates to derive overall effect estimates. We evaluated the sensitivity of our estimates to co-pollutant exposures and city-specific model choice, and investigated effect modification by age, sex, and season. We applied distributed lag and threshold models to investigate temporal patterns of associations. Results: A 10-μg/m3 increase in PM2.5 was associated with a 0.55% (95% CI: 0.27, 0.84%) increase in all-cause mortality (0-1 day cumulative lag), and a 1.91% increase (95% CI: 0.71, 3.12%) in respiratory mortality (0-5 day lag). In general, associations were stronger for cardiovascular and respiratory mortality than all-cause mortality, during warm versus cold months, and among those ≥ 75 versus < 75 years of age. Associations with PM2.5-10 were positive but not statistically significant in most analyses, whereas associations with PM10 seemed to be driven by PM2.5. Conclusions: We found evidence of adverse effects of PM2.5 on mortality outcomes in the European Mediterranean region. Associations with PM2.5-10 were positive but smaller in magnitude. Associations were stronger for respiratory mortality when cumulative exposures were lagged over 0-5 days, and were modified by season and age.
ER -