TY - JOUR
TI - Identification of women for referral to colposcopy by neural networks: A preliminary study based on LBC and molecular biomarkers
AU - Karakitsos, P.
AU - Chrelias, C.
AU - Pouliakis, A.
AU - Koliopoulos, G.
AU - Spathis, A.
AU - Kyrgiou, M.
AU - Meristoudis, C.
AU - Chranioti, A.
AU - Kottaridi, C.
AU - Valasoulis, G.
AU - Panayiotides, I.
AU - Paraskevaidis, E.
JO - Journal of Biomedicine and Biotechnology
PY - 2012
VL - 2012
TODO - null
SP - null
PB - 
SN - 1110-7243, 1110-7251
TODO - 10.1155/2012/303192
TODO - biological marker;  messenger RNA;  biological marker;  tumor marker, algorithm;  article;  classifier;  colposcopy;  cytology;  diagnostic accuracy;  female;  human;  human tissue;  immunohistochemistry;  liquid;  patient referral;  precancer;  uterine cervix cancer;  uterine cervix carcinoma in situ;  artificial neural network;  automated pattern recognition;  blood;  computer assisted diagnosis;  methodology;  patient referral;  patient selection;  pilot study;  reproducibility;  sensitivity and specificity;  support vector machine;  uterine cervix tumor;  vagina smear, Human papillomavirus, Biological Markers;  Colposcopy;  Diagnosis, Computer-Assisted;  Female;  Humans;  Neural Networks (Computer);  Patient Selection;  Pattern Recognition, Automated;  Pilot Projects;  Referral and Consultation;  Reproducibility of Results;  Sensitivity and Specificity;  Support Vector Machines;  Tumor Markers, Biological;  Uterine Cervical Neoplasms;  Vaginal Smears
TODO - Objective of this study is to investigate the potential of the learning vector quantizer neural network (LVQ-NN) classifier on various diagnostic variables used in the modern cytopathology laboratory and to build an algorithm that may facilitate the classification of individual cases. From all women included in the study, a liquid-based cytology sample was obtained; this was tested via HPV DNA test, E6/E7 HPV mRNA test, and p16 immunostaining. The data were classified by the LVQ-NN into two groups: CIN-2 or worse and CIN-1 or less. Half of the cases were used to train the LVQ-NN; the remaining cases (test set) were used for validation. Out of the 1258 cases, cytology identified correctly 72.90% of the CIN-2 or worst cases and 97.37% of the CIN-1 or less cases, with overall accuracy 94.36%. The application of the LVQ-NN on the test set allowed correct classification for 84.62% of the cases with CIN-2 or worse and 97.64% of the cases with CIN-1 or less, with overall accuracy of 96.03%. The use of the LVQ-NN with cytology and the proposed biomarkers improves significantly the correct classification of cervical precancerous lesions and/or cancer and may facilitate diagnosis and patient management. © 2012 Petros Karakitsos et al.
ER -