TY - JOUR
TI - Physical activity and lung cancer among non-smokers: A pilot molecular epidemiological study within EPIC
AU - Rundle, A.
AU - Richie, J.
AU - Steindorf, K.
AU - Peluso, M.
AU - Overvad, K.
AU - Raaschou-Nielsen, O.
AU - Clavel-Chapelon, F.
AU - Linseisen, J.P.
AU - Boeing, H.
AU - Trichopoulou, A.
AU - Palli, D.
AU - Krogh, V.
AU - Tumino, R.
AU - Panico, S.
AU - Bueno-De-Mesquita, H.B.
AU - Peeters, P.H.
AU - Lund, E.
AU - Gonzalez, C.A.
AU - Martinez, C.
AU - Dorronsoro, M.
AU - Barricarte, A.
AU - Tormo, M.J.
AU - Quiros, J.R.
AU - Agudo, A.
AU - Berglund, G.
AU - Jarvholm, B.
AU - Bingham, S.
AU - Key, T.J.
AU - Gormally, E.
AU - Saracci, R.
AU - Kaaks, R.
AU - Riboli, E.
AU - Vineis, P.
JO - Biomarker Insights
PY - 2010
VL - 15
TODO - 1
SP - 20-30
PB - 
SN - 1177-2719
TODO - 10.3109/13547500903186452
TODO - biological marker;  glutathione;  hemoglobin;  phosphorus 32, adult;  aged;  article;  cancer risk;  controlled study;  DNA adduct;  erythrocyte;  female;  human;  leukocyte;  lung cancer;  major clinical study;  male;  molecular epidemiology;  physical activity;  smoking, Aged;  Biological Markers;  Case-Control Studies;  DNA Adducts;  Erythrocytes;  Europe;  Female;  Glutathione;  Humans;  Leukocytes;  Lung Neoplasms;  Male;  Middle Aged;  Molecular Epidemiology;  Motor Activity;  Pilot Projects;  Risk Factors;  Smoking
TODO - The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by 32P-post- labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.350.90), higher GSH levels (1.87 μmol GSH g-1 haemoglobin, p 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI 0.382.86). Despite being associated with recreational physical activity, in these small-scale pilot analyses GSH levels were not associated with lung cancer risk (OR 0.95, 95% CI 0.841.07 per unit increase in GSH levels). Household and occupational activity was not associated with lung cancer risk or biomarker levels. © 2010 Informa UK Ltd.
ER -