TY - JOUR
TI - Effects of terpenoids from Salvia willeana in delayed-type hypersensitivity, human lymphocyte proliferation and cytokine production
AU - Vonaparti, A.
AU - Karioti, A.
AU - Recio, M.C.
AU - Máñez, S.
AU - Ríos, J.L.
AU - Skaltsa, E.
AU - Giner, R.M.
JO - Natural Product Communications
PY - 2008
VL - 3
TODO - 12
SP - 1953-1958
PB - Natural Product Incorporation
SN - null
TODO - 10.1177/1934578x0800301202
TODO - camphor;  interleukin 1beta;  interleukin 4;  lupeol;  nitric oxide;  oleanolic acid;  plant extract;  Salvia willeana extract;  tumor necrosis factor alpha;  unclassified drug, animal experiment;  antiinflammatory activity;  apoptosis;  article;  cell cycle;  cell viability;  concentration response;  controlled study;  cytokine production;  cytokine release;  cytotoxicity;  delayed hypersensitivity;  ear;  edema;  enzyme linked immunosorbent assay;  female;  human;  human cell;  IC 50;  lymphocyte proliferation;  macrophage;  mitochondrion;  mouse;  nonhuman;  Salvia;  Salvia willeana, Dryobalanops;  Salvia
TODO - The effect of the lipophilic extract of S. willeana and three terpenoids isolated therefrom, camphor, lupeol and oleanolic acid, on oxazolone-induced hypersensitivity was evaluated. The extract reduced the ear edema by 46% at 24 h after challenge. All three terpenoids inhibited the edema and suppressed cytokines release at different rates. Lupeol inhibited the swelling by over 50% and reduced the production of IL-1β by 62%. Camphor caused inhibition of the efferent phase (45% inhibition at 72 h) and the levels of IL-1β, IL-4 and TNF-α (around 80% inhibition). Oleanolic acid diminished moderately the reaction and the levels of IL-4 and TNF-α. We also demonstrated that the three terpenoids inhibited human T-lymphocytes proliferation in a concentration-dependent manner and induced their apoptosis. Thus, these terpenoids could be considered anti-inflammatory constituents of S. willeana.
ER -