TY - JOUR
TI - Synthesis of hydroxyapatite, β-Tricalcium phosphate and biphasic calcium phosphate particles to act as local delivery carriers of curcumin: Loading, release and in vitro studies
AU - Xidaki, D.
AU - Agrafioti, P.
AU - Diomatari, D.
AU - Kaminari, A.
AU - Tsalavoutas-Psarras, E.
AU - Alexiou, P.
AU - Psycharis, V.
AU - Tsilibary, E.C.
AU - Silvestros, S.
AU - Sagnou, M.
JO - JPhys Materials
PY - 2018
VL - 11
TODO - 4
SP - null
PB - MDPI AG
SN - null
TODO - 10.3390/ma11040595
TODO - Calcium phosphate;  Ceramic materials;  Hydroxyapatite;  Phosphatases;  Transmission control protocol, Alkaline phosphatase activity;  Beta tricalcium phosphate;  Biphasic calcium phosphates;  Curcumin;  Delivery;  Synthetic biomaterials;  Tri-calcium phosphates;  Wet precipitation, Biomaterials
TODO - The successful synthesis of hydroxyapatite (HA), β-Tricalcium phosphate (β-TCP) and two biphasic mixtures (BCPs) of the two was performed by means of wet precipitation. The resulting crystals were characterized and the BCP composition was analyzed and identified as 13% HA-87% TCP and 41% HA-59% TCP. All samples were treated with curcumin solutions, and the degree of curcumin loading and release was found to be proportional to the TCP content of the ceramic. No further cytotoxicity was observed upon MG-63 treatment with the curcumin-loaded ceramics. Finally, the alkaline phosphatase activity of the cells was found to increase with increasing content of TCP, which provides an encouraging proof of concept for the use of curcumin-loaded synthetic biomaterials in bone remodeling. © 2018 by the authors.
ER -