TY - JOUR
TI - The effects of nitroglycerin during cardiopulmonary resuscitation
AU - Stefaniotou, A.
AU - Varvarousi, G.
AU - Varvarousis, D.P.
AU - Xanthos, T.
JO - European Journal of Pharmacology
PY - 2014
VL - 734
TODO - 1
SP - 42-49
PB - Elsevier B.V.
SN - 0014-2999
TODO - 10.1016/j.ejphar.2014.04.002
TODO - adrenalin;  glyceryl trinitrate;  vasopressin;  glyceryl trinitrate;  neuroprotective agent;  vasoconstrictor agent, coronary artery blood flow;  dose response;  drug effect;  drug efficacy;  drug megadose;  drug potency;  heart arrest;  heart protection;  human;  low drug dose;  microvasculature;  neuroprotection;  neurotoxicity;  nonhuman;  pathophysiology;  priority journal;  reperfusion injury;  resuscitation;  review;  survival rate;  treatment outcome;  animal;  procedures;  reperfusion injury;  resuscitation, Animals;  Cardiopulmonary Resuscitation;  Humans;  Neuroprotective Agents;  Nitroglycerin;  Reperfusion Injury;  Vasoconstrictor Agents
TODO - The outcome for both in-hospital and out-of hospital cardiac arrest remains dismal. Vasopressors are used to increase coronary perfusion pressure and thus facilitate return of spontaneous circulation during cardiopulmonary resuscitation. However, they are associated with a number of potential adverse effects and may decrease endocardial and cerebral organ blood flow. Nitroglycerin has a favourable haemodynamic profile which promotes forward blood flow. Several studies suggest that combined use of nitroglycerin with vasopressors during resuscitation, is associated with increased rates of resuscitation and improved post-resuscitation outcome. This article reviews the effects of nitroglycerin during cardiopulmonary resuscitation and postresuscitation period, as well as the beneficial outcomes of a combination regimen consisting of a vasopressor and a vasodilator, such as nitroglycerin. © 2014 Elsevier B.V. All rights reserved.
ER -