TY - JOUR
TI - In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects
AU - Sjögren, E.
AU - Abrahamsson, B.
AU - Augustijns, P.
AU - Becker, D.
AU - Bolger, M.B.
AU - Brewster, M.
AU - Brouwers, J.
AU - Flanagan, T.
AU - Harwood, M.
AU - Heinen, C.
AU - Holm, R.
AU - Juretschke, H.-P.
AU - Kubbinga, M.
AU - Lindahl, A.
AU - Lukacova, V.
AU - Münster, U.
AU - Neuhoff, S.
AU - Nguyen, M.A.
AU - Peer, A.V.
AU - Reppas, C.
AU - Hodjegan, A.R.
AU - Tannergren, C.
AU - Weitschies, W.
AU - Wilson, C.
AU - Zane, P.
AU - Lennernäs, H.
AU - Langguth, P.
JO - EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
PY - 2014
VL - 57
TODO - 1
SP - 99-151
PB - Elsevier
SN - 0928-0987
TODO - 10.1016/j.ejps.2014.02.010
TODO - active pharmaceutical ingredient;  drug;  drug metabolizing enzyme;  excipient;  fosamprenavir;  unclassified drug;  drug;  excipient, absorption;  anatomy;  article;  beverage;  diffusion;  dispersion;  dog;  drug absorption;  drug dosage form;  drug formulation;  drug release;  drug solubility;  endocytosis;  ex vivo study;  food;  food intake;  gallbladder;  gastrointestinal motility;  gastrointestinal tract;  gastrointestinal transit;  human;  imaging;  in vitro study;  in vivo study;  intestine mucosa permeability;  lymph vessel;  membrane transport;  metabolism;  microcapsule;  nonhuman;  perfusion;  physical chemistry;  physiology;  precipitation;  priority journal;  small intestine;  stomach;  stomach pH;  surface property;  swine;  tight junction;  animal;  animal model;  biological model;  chemistry;  food drug interaction;  intestine absorption;  medicinal chemistry;  metabolism;  oral drug administration;  pharmaceutics;  pharmacokinetics;  procedures;  reproducibility;  species difference, Administration, Oral;  Animals;  Biopharmaceutics;  Chemistry, Pharmaceutical;  Excipients;  Food-Drug Interactions;  Gastrointestinal Motility;  Gastrointestinal Tract;  Humans;  Intestinal Absorption;  Models, Animal;  Models, Biological;  Pharmaceutical Preparations;  Pharmacokinetics;  Reproducibility of Results;  Species Specificity
TODO - This review summarizes the current knowledge on anatomy and physiology of the human gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and mouse) with emphasis on in vivo methods for testing and prediction of oral dosage form performance. A wide range of factors and methods are considered in addition, such as imaging methods, perfusion models, models for predicting segmental/regional absorption, in vitro in vivo correlations as well as models to investigate the effects of excipients and the role of food on drug absorption. One goal of the authors was to clearly identify the gaps in today's knowledge in order to stimulate further work on refining the existing in vivo models and demonstrate their usefulness in drug formulation and product performance testing. © 2013 Elsevier B.V. All rights reserved.
ER -