TY - JOUR
TI - KPC-producing, multidrug-resistant klebsiella pneumoniae sequence type 258 as a typical opportunistic pathogen
AU - Tzouvelekis, L.S.
AU - Miriagou, V.
AU - Kotsakis, S.D.
AU - Spyridopoulou, K.
AU - Athanasiou, E.
AU - Karagouni, E.
AU - Tzelepi, E.
AU - Daikos, G.L.
JO - Antimicrobial Agents and Chemotherapy
PY - 2013
VL - 57
TODO - 10
SP - 5144-5146
PB - 
SN - 0066-4804, 1098-6596
TODO - 10.1128/AAC.01052-13
TODO - antibiotic agent;  imipenem;  meropenem, animal experiment;  article;  bacterial strain;  bacterial virulence;  bactericidal activity;  bacterium isolate;  colony forming unit;  controlled study;  Greece;  human;  human cell;  in vitro study;  Klebsiella pneumoniae;  Klebsiella pneumoniae infection;  KPC producing Klebsiella pneumoniae;  lethal dose;  minimum inhibitory concentration;  mouse;  multidrug resistance;  neutropenia;  nonhuman;  phagocytosis;  priority journal;  sequence analysis;  serum, Animals;  beta-Lactamases;  Drug Resistance, Multiple, Bacterial;  Female;  Humans;  Kaplan-Meier Estimate;  Klebsiella pneumoniae;  Mice;  Mice, Inbred ICR;  Sepsis
TODO - The virulence of a KPC-producing Klebsiella pneumoniae sequence type 258 (ST258) strain representing those circulating in Greece was assessed in a mouse septicemia model. The strain was virtually avirulent (50% lethal dose,>108 and 5×107 CFU for immunocompetent and neutropenic animals, respectively). Also, it was highly susceptible to serum killing, rapidly phagocytosed in vitro, and classified as K41, which is not among the virulent capsular types. The findings indirectly support the notion that high ST258-associated mortality is largely due to inefficient antimicrobial treatment. Copyright © 2013, American Society for Microbiology. All Rights Reserved.
ER -