TY - JOUR
TI - Serum and cerebrospinal fluid levels of colistin in pediatric patients
AU - Antachopoulos, C.
AU - Karvanen, M.
AU - Iosifidis, E.
AU - Jansson, B.
AU - Plachouras, D.
AU - Cars, O.
AU - Roilides, E.
JO - Antimicrobial Agents and Chemotherapy
PY - 2010
VL - 54
TODO - 9
SP - 3985-3987
PB - 
SN - 0066-4804, 1098-6596
TODO - 10.1128/AAC.01799-09
TODO - amikacin;  amphotericin B;  colistimethate;  colistin;  dexamethasone;  dobutamine;  domperidone;  dopamine;  etiracetam;  gabapentin;  isoniazid;  levofloxacin;  meropenem;  metronidazole;  midazolam;  omeprazole;  phenytoin;  piperacillin plus tazobactam;  pyrazinamide;  ranitidine;  vancomycin;  voriconazole, Acinetobacter;  Acinetobacter infection;  adolescent;  article;  aspergillosis;  Aspergillus fumigatus;  blood level;  blood sampling;  case report;  cerebrospinal fluid level;  child;  female;  human;  hydrocephalus;  infant;  Klebsiella pneumoniae;  Klebsiella pneumoniae infection;  male;  mass fragmentography;  meningitis;  pediatrics;  preschool child;  priority journal;  Pseudomonas;  school child;  Stenotrophomonas maltophilia, Adolescent;  Anti-Bacterial Agents;  Child;  Child, Preschool;  Colistin;  Female;  Gram-Negative Bacterial Infections;  Humans;  Infant;  Male;  Treatment Outcome
TODO - Using a liquid chromatography-tandem mass spectrometry method, the serum and cerebrospinal fluid (CSF) concentrations of colistin were determined in patients aged 11?2 months to 14 years receiving intravenous colistimethate sodium (60,000 to 225,000 IU/kg of body weight/day). Only in one of five courses studied (a 14-year-old receiving 225,000 IU/kg/day) did serum concentrations exceed the 2 μg/ml CLSI/EUCAST breakpoint defining susceptibility to colistin for Pseudomonas and Acinetobacter. CSF colistin concentrations were <0.2 μg/ml but increased in the presence of meningitis (∼0.5 μg/ml or 34 to 67% of serum levels). Copyright © 2010, American Society for Microbiology. All Rights Reserved.
ER -