TY - JOUR
TI - Cytotoxic halogenated metabolites from the Brazilian red alga Laurencia catarinensis
AU - Lhullier, C.
AU - Falkenberg, M.
AU - Ioannou, E.
AU - Quesada, A.
AU - Papazafiri, P.
AU - Horta, P.A.
AU - Schenkel, E.P.
AU - Vagias, C.
AU - Roussis, V.
JO - Tropical Journal of Natural Product Research
PY - 2010
VL - 73
TODO - 1
SP - 27-32
PB - 
SN - null
TODO - 10.1021/np900627r
TODO - 10 epideoxycaespitol;  10 o methylfurocaespitanelactol;  5 acetoxyacetylcaespitol;  5 acetoxycaespitol;  5 acetoxydeoxycaespitol;  5 hydroxyacetylcaespitol;  acetylcaespitol;  caespitenone;  caespitol;  deoxycaespitol;  deoxyisocaespitol;  furocaespitanelactol;  halide;  isocaespitol;  miltefosine;  natural product;  unclassified drug, article;  cell strain HT29;  cell strain MCF 7;  controlled study;  drug cytotoxicity;  drug isolation;  drug structure;  halogenation;  human;  human cell;  human cell culture;  in vitro study;  Laurencia catarinensis;  mass spectrometry;  metabolite;  nonhuman;  nuclear magnetic resonance spectroscopy;  red alga;  structure activity relation;  X ray diffraction, Antineoplastic Agents;  Brazil;  Crystallography, X-Ray;  Drug Screening Assays, Antitumor;  Female;  HT29 Cells;  Humans;  Hydrocarbons, Halogenated;  Laurencia;  Molecular Structure;  Nuclear Magnetic Resonance, Biomolecular, Laurencia catarinensis;  Rhodophyta
TODO - Seven new (1-7) and seven previously reported (8-14) halogenated metabolites were isolated from the organic extract of the Brazilian red alga Laurencia catarinensis. The structure elucidation and the assignment of the relative configurations of the new natural products were based on detailed NMR and MS spectroscopic analyses, whereas the structure of metabolite 6 was confirmed by single-crystal X-ray diffraction analysis. The absolute configuration of metabolite 1 was determined using the modified Mosher's method. The in vitro cytotoxicity of compounds 1-14 was evaluated against HT29, MCF7, and A431 cell lines. © 2010 American Chemical Society and American Society of Pharmacognosy.
ER -