TY - JOUR
TI - 5α,8α-Epidioxysterols from the gorgonian Eunicella cavolini and the ascidian Trididemnum inarmatum: Isolation and evaluation of their antiproliferative activity
AU - Ioannou, E.
AU - Abdel-Razik, A.F.
AU - Zervou, M.
AU - Christofidis, D.
AU - Alexi, X.
AU - Vagias, C.
AU - Alexis, M.N.
AU - Roussis, V.
JO - Steroids
PY - 2009
VL - 74
TODO - 1
SP - 73-80
PB - 
SN - 0039-128X
TODO - 10.1016/j.steroids.2008.09.007
TODO - 5alpha 8alpha epidioxy 24,26 cyclo cholesta 6,22 dien 3beta ol;  5alpha,8a epidioxysterol derivative;  5alpha,8alpha epidioxy 24 ethylcholesta 6,24(28) dien 3beta ol;  5alpha,8alpha epidioxy 24xi methyl 27 norcholesta 6,22 dien 3beta ol;  natural product;  sterol derivative;  unclassified drug;  cholesterol ester;  epidioxysterol, article;  Ascidiacea;  coelenterate;  controlled study;  drug activity;  drug isolation;  drug structure;  Eunicella cavolini;  human;  human cell;  proton nuclear magnetic resonance;  Trididemnum inarmatum;  animal;  Anthozoa;  cell proliferation;  chemical structure;  chemistry;  drug effect;  drug screening;  female;  isolation and purification;  nuclear magnetic resonance spectroscopy;  tumor cell line;  Urochordata, Ascidia;  Eunicella cavolini;  Gorgonia;  Trididemnum, Animals;  Anthozoa;  Cell Line, Tumor;  Cell Proliferation;  Cholesterol Esters;  Drug Screening Assays, Antitumor;  Female;  Humans;  Magnetic Resonance Spectroscopy;  Molecular Structure;  Urochordata
TODO - Three new (1, 4, 9) and nine previously reported (2, 3, 5-8, 10-12) 5α,8α-epidioxysterols were isolated from the organic extracts of the gorgonian Eunicella cavolini and the ascidian Trididemnum inarmatum. The structures and relative configurations of 1-12 were established on the basis of detailed NMR spectroscopic analyses and comparison with the literature. The growth inhibitory effects of 1-12 were evaluated against MCF-7 human breast cancer cells. Compound 1, bearing a cyclopropyl moiety in the side chain, exhibited the highest antiproliferative activity. © 2008 Elsevier Inc. All rights reserved.
ER -