TY - JOUR
TI - Effect of isocaloric diets and sibutramine on food intake, body mass variation and serum TNF-α levels in rats
AU - Trapali, M.
AU - Liapi, C.
AU - Perelas, A.
AU - Perrea, D.
AU - Stroubini, T.
AU - Dontas, I.
AU - Couvari, E.
AU - Mavri, M.
AU - Galanopoulou, P.
JO - Pharmacological Research Communications
PY - 2008
VL - 82
TODO - 1
SP - 15-21
PB - 
SN - null
TODO - 10.1159/000127363
TODO - sibutramine;  tumor necrosis factor alpha, animal experiment;  article;  body mass;  body weight;  caloric intake;  carbohydrate diet;  controlled study;  drug effect;  food intake;  lipid diet;  male;  nonhuman;  priority journal;  protein diet;  rat;  weight gain, Animals;  Appetite Depressants;  Body Weight;  Cyclobutanes;  Diet;  Dietary Carbohydrates;  Dietary Fats;  Dietary Proteins;  Eating;  Energy Intake;  Enzyme-Linked Immunosorbent Assay;  Feeding Behavior;  Male;  Rats;  Rats, Wistar;  Tumor Necrosis Factor-alpha;  Weight Gain
TODO - Background/Aim: The effect of isocaloric diets and sibutramine on dietary behaviour and TNF-α is poorly understood. The aim of the study was to investigate the effects of isocaloric diets and sibutramine on food intake, body mass variation and serum TNF-α in free-feeding rats. Methods: Three groups of male Wistar rats (n = 63) were fed a high-fat diet, high-carbohydrate diet or high-protein diet for 13 weeks. In the last 3 weeks, each group was divided into 3 subgroups. Each subgroup received sibutramine 5 mg/kg, sibutramine 10 mg/kg or vehicle. Food intake was measured daily during the last week of the experiment; serum TNF-α was assayed and the body weight increasing rate was calculated. Results: The high-fat diet was associated with increased food intake, a greater weight gain ratio and increased TNF-α levels. Sibutramine treatment did not affect the dietary behaviour of high-protein- or high-carbohydrate-fed rats, while it significantly attenuated the daily food intake and body weight gain rate in the high-fat group, at the dose of 10 mg/kg. TNF-α levels were not affected by sibutramine. Conclusions: High-fat feeding was associated with an increase in daily food intake, TNF-α levels and body weight gain rate, as well as with enhanced responsiveness to the anorectic effects of sibutramine. However, sibutramine did not affect TNF-α. Copyright © 2008 S. Karger AG.
ER -