TY - JOUR
TI - A simple method for the alkaline hydrolysis of esters
AU - Theodorou, V.
AU - Skobridis, K.
AU - Tzakos, A.G.
AU - Ragoussis, V.
JO - TETRAHEDRON LETTERS
PY - 2007
VL - 48
TODO - 46
SP - 8230-8233
PB - 
SN - 0040-4039
TODO - 10.1016/j.tetlet.2007.09.074
TODO - alcohol derivative;  carboxylic acid;  dichloromethane;  ester;  ester derivative;  methanol;  sodium hydroxide;  solvent, alkalinity;  article;  drug synthesis;  hydrolysis;  nonaqueous phase liquid;  organic chemistry;  process development;  reaction analysis;  room temperature;  saponification;  stereochemistry;  temperature dependence
TODO - A very mild and rapid procedure for the efficient alkaline hydrolysis of esters in non-aqueous conditions has been developed, by the use of dichloromethane/methanol (9:1) as solvent. This method conveniently provides both carboxylic acids and alcohols from the corresponding esters and sodium hydroxide in a few minutes at room temperature. A plausible reaction mechanism is proposed. © 2007 Elsevier Ltd. All rights reserved.
ER -