TY - JOUR
TI - Synthesis of novel nitro-substituted triaryl pyrazole derivatives as potential estrogen receptor ligands
AU - Naoum, F.
AU - Kasiotis, K.M.
AU - Magiatis, P.
AU - Haroutounian, S.A.
JO - Molecules (Basel, Switzerland)
PY - 2007
VL - 12
TODO - 7
SP - 1259-1273
PB - 
SN - null
TODO - 10.3390/12071259
TODO - estrogen receptor alpha;  estrogen receptor beta;  ligand;  nitro derivative;  pyrazole;  pyrazole derivative, article;  chemistry;  human;  metabolism;  synthesis, Estrogen Receptor alpha;  Estrogen Receptor beta;  Humans;  Ligands;  Nitro Compounds;  Pyrazoles
TODO - Novel tetrasubstituted pyrazole derivatives bearing a nitro substituent on their A-phenol ring were synthesized and their binding affinity towards the estrogen receptor (ER) subtypes ERα and ERβ was determined. Among compounds tested, the 2-nitrophenol derivative 5c was found to bind satisfactorily to both estrogen receptor subtypes (RBAα=5.17 and RBAβ=3.27). In general, the introduction of a nitro group into the A ring of these compounds was found to benefit their ERβ binding abilities. © 2007 by MDPI.
ER -