TY - JOUR
TI - A facile synthesis of C2-substituted pyrrolo[2,3-f]quinolines with cytotoxic activity
AU - Tsotinis, A.
AU - Vlachou, M.
AU - Zouroudis, S.
AU - Jeney, A.
AU - Timár, F.
AU - Thurston, D.E.
AU - Roussakis, C.
JO - Letters in Drug Design and Discovery
PY - 2005
VL - 2
TODO - 3
SP - 189-192
PB - 
SN - null
TODO - 10.2174/1570180053765075
TODO - 1h pyrrolo[2,3 f]quinoline 2 carboxamide derivative;  6 quinolinecarboxaldehyde;  pyrrolo[2,3 f]quinoline derivative;  quinoline derivative;  unclassified drug, article;  cyclization;  cytotoxicity;  drug hydrolysis;  drug structure;  drug synthesis;  priority journal;  tumor cell line
TODO - An expeditious four-step synthesis of the 1H-pyrrolo[2,3-f]quinoline-2- carboxamides (5a-h) is described. Readily available 6-quinolinecarboxaldehyde is converted to the parent acid (6) by nucleophilic attack of the azido-ester (9) and intramolecular cyclization of (10) followed by hydrolysis of the methyl ester (11). The cytotoxicity of the target molecules (5a-h) was evaluated in four tumour cell lines in vitro. One compound (5d) showed sufficient activity (IC50 = 10.2 μM) in the human non-small cell lung cell line NSCLC-N16-L16 to be worthy of further study. © 2005 Bentham Science Publishers Ltd.
ER -