TY - JOUR
TI - Synthesis of the marine furanoditerpene (-)-marginatone
AU - Kolympadi, M.
AU - Liapis, M.
AU - Ragoussis, V.
JO - Tetrahedron
PY - 2005
VL - 61
TODO - 8
SP - 2003-2010
PB - 
SN - 0040-4020
TODO - 10.1016/j.tet.2005.01.007
TODO - diterpene;  furanoditerpene;  marginatone;  unclassified drug, article;  carbon nuclear magnetic resonance;  chemical reaction;  drug synthesis;  molecular interaction;  oxidation;  priority journal;  proton nuclear magnetic resonance
TODO - A synthesis of the marine labdane furanoditerpene (-)-marginatone 1 has been accomplished by a short sequence of reactions starting from (+)-coronarin E 5. The key step is the stereocontrolled-intramolecular electrophilic cyclisation of the (+)-dihydrocoronarin E 6, to the tetracyclic marginatane skeleton 7, which is subsequently functionalized by allylic oxidation to give 1. As (+)-coronarin E 5 was previously synthesized from (-)-sclareol 10, the herein reported preparation constitutes the first formal total synthesis of (-)-marginatone 1, by which its absolute configuration has been confirmed. © 2005 Elsevier Ltd. All rights reserved.
ER -