TY - JOUR TI - Monte Carlo simulation to assess free space and end-weld thickness variation effects on dose rate for a new Ir-192 brachytherapy source AU - Angelocci, L.V. AU - Daruich de Souza, C. AU - Pantelis, E. AU - Nogueira, B.R. AU - Zeituni, C.A. AU - Chueri Martins Rostelato, M.E. JO - International Journal of Applied Radiation and Isotopes PY - 2021 VL - 173 TODO - null SP - null PB - Elsevier Ireland Ltd SN - 0020-708X TODO - 10.1016/j.apradiso.2021.109709 TODO - Dosimetry; Intelligent systems; MATLAB; Oncology; Radiotherapy; Welds, Brachytherapy; Dose rate; Free end; Free spaces; Iridium-192; Iridium-192 seed; Monte Carlo's simulation; Source production; Thickness variation; Weld thickness, Monte Carlo methods, iridium 192; iridium; Iridium-192, anisotropy; Article; brachytherapy; controlled study; data analysis software; dosimetry; encapsulation; Monte Carlo method; process optimization; radiation dose; radiation response; computer simulation; human; Monte Carlo method; radiotherapy dosage, Brachytherapy; Computer Simulation; Humans; Iridium Radioisotopes; Monte Carlo Method; Radiotherapy Dosage TODO - A new Iridium-192 seed for brachytherapy is under development. Specific dose rate contribution by two different factors were evaluated: the effect from movement of the core in the free space within the seed and the effect of the end-weld thickness variation. Both were investigated through use of the Monte Carlo radiation transport code MCNP6 and an in-house routine programmed with MATLAB. Differences greater than 15% compared to results from the nominal seed were found near the source, indicating a significant dose variation. © 2021 Elsevier Ltd ER -